Reversion of anti-estrogen therapy resistance in breast cancer by inhibitors of IRE1/XBP1 signaling: A structure-activity relationship study

Dr. Ihab Kabaha Chronic unfolded protein response (UPR) within the endoplasmic reticulum (ER) is directly correlated with breast cancer drug resistance. Expression of X-box binding protein-1 (Xbp1), a critical component of the UPR signalling correlates with poor clinical responsiveness to tamoxifen, widely used anti-oestrogen therapeutic agent. Xbp-1 is activated by IRE1α RNase (Ire1) by cytoplasmic […]